AC0939 (STI-8591)

AC0939 is a novel small molecule inhibitor of tropomyosin receptor kinases (TRK). This family of signaling proteins is implicated in oncogenic rearrangements that result in activated fusion kinases found in many adult and pediatric cancers. AC0939 shows potent and selective activity against wild-type and mutant TRKs in kinase enzyme and cell-based assays.